David S. Lalush Research Assistant Professor Department of Biomedical Engineering CB#7575, 152 MacNider Hall The University of North Carolina at Chapel Hill Chapel Hill, NC 27599-7575 Phone: 919-966-0266 FAX: 919-966-2963 email: lalush@bme.unc.edu

Research Interests  Research Projects  Education  Refereed Journals and Books  Submitted Publications  Conference Proceedings (not published elsewhere)  Courses

Research Interests

• Statistical reconstruction algorithms in single-photon emission computed tomography (SPECT) and positron emission tomography (PET)
• Converging-beam SPECT
• Space- and time-domain image reconstruction and image processing
• Mathematical modeling of anatomy and involuntary motion

• Dual-planar circular-orbit cone-beam SPECT
• Evaluation of iterative reconstruction algorithms
• Reconstruction algorithms for gated myocardial SPECT
• Transmissionless attenuation correction for dual-camera PET FDG lung studies
• Next-generation MCAT phantom development

• 1992 Ph.D. Department of Biomedical Engineering, The University of North Carolina at Chapel Hill
• 1986 MSEE Department of Electrical and Computer Engineering, North Carolina State University
• 1984 BSEE Department of Electrical and Computer Engineering, Lehigh University

1. Lalush, D. S., and B. M. W. Tsui, "Simulation evaluation of Gibbs prior distributions for use in maximum a posteriori SPECT reconstructions," IEEE Transactions on Medical Imaging, vol. 11, pp. 267-275, 1992.
2. Lalush, D. S., and B. M. W. Tsui, "Attenuation and detector response compensations used with Gibbs prior distributions for maximum a posteriori reconstruction in SPECT," IEEE Transactions on Nuclear Science, vol. 39, pp. 1454-1459, 1992.
3. Lalush, D. S., and B. M. W. Tsui, "A generalized Gibbs prior for maximum a posteriori reconstruction in SPECT," Physics in Medicine and Biology, vol. 38, pp. 729-741, 1993.
4. Lalush, D. S., and B. M. W. Tsui, "Improving the convergence of iterative filtered backprojection algorithms," Medical Physics, vol. 21, pp. 1283-1286, 1994.
5. Lalush, D. S., and B. M. W. Tsui, "A fast and stable maximum a posteriori conjugate gradient reconstruction algorithm," Medical Physics, vol. 22, pp. 1273-1284, 1995.
6. Lalush, D. S., and B. M. W. Tsui, "Space-Time Gibbs Priors Applied to Gated SPECT Myocardial Perfusion Studies," Three-Dimensional Image Reconstruction in Radiology and Nuclear Medicine, Kluwer Academic Publishers: Dordrecht, Netherlands, pp. 209-223, 1996.
7. Lalush, D. S., and B. M. W. Tsui, "Block-iterative techniques for fast 4D reconstruction using a priori motion models in gated cardiac SPECT," Physics in Medicine and Biology, vol. 43, pp. 875-886, 1998.
8. Lalush, D. S., and B. M. W. Tsui, "Mean-variance analysis of block-iterative reconstruction algorithms modeling 3D detector response in SPECT," IEEE Transactions on Nuclear Science, vol. 45, pp.1280-1287, 1998.
9. Lalush, D. S., “Fourier rebinning applied to multiplanar circular-orbit cone-beam SPECT,” IEEE Transactions on Medical Imaging, vol. 18, pp. 1076-1084, 1999.
10. Lalush, D. S. and B. M. W. Tsui, “Performance of ordered subset reconstruction algorithms under conditions of extreme attenuation and truncation in cardiac SPECT,” Journal of Nuclear Medicine, 41, pp. 737-744, 2000.
11. Lalush, D. S., E. C. Frey, and B. M. W. Tsui, “Fast maximum entropy approximation in SPECT using the RBI-MAP algorithm,” IEEE Transactions on Medical Imaging, vol. 19, pp. 286-294, 2000.
12. Lalush, D. S. and B. M. W. Tsui, “Fast transmission CT reconstruction for SPECT using a block-iterative algorithm,” IEEE Transactions on Nuclear Science, vol. 47, pp. 1123-1129, 2000.
13. Tsui, B. M. W., E. C. Frey, X.-D. Zhao, D. S. Lalush, R. E. Johnston, and W. H. McCartney, "The importance and implementation of accurate three-dimensional compensation methods for quantitative SPECT," Physics in Medicine and Biology, vol. 39, pp. 509-530, 1994.
14. Zhao, X.D.; Tsui, B.M.W.; Gregoriou, G.K.; Lalush, D.S.; Li, J.; Eisner, R.L., "Evaluation of corrective reconstruction methods using a 3D cardiac-torso phantom and bull’s-eye plots," IEEE Transactions on Nuclear Science, vol. 41, pp. 2831-2837, 1994.
15. DiBella, E. V. R., R. L. Eisner, L. S. Schmarkey, A. B. Barclay, R. E. Patterson, D.J. Nowak, D. S. Lalush, and B. M. W. Tsui, "Heterogeneity of SPECT bull’s-eyes in normal dogs: comparison of attenuation compensation algorithms," IEEE Transactions on Nuclear Science, vol. 42, pp. 1290-1296, 1995.
16. Tsui, B. M. W., E. C. Frey, K. J. LaCroix, D. S. Lalush, W. H. McCartney, M. A. King, and G. T. Gullberg, "Quantitative myocardial perfusion SPECT," Journal of Nuclear Cardiology, vol. 5, pp. 507-522, 1998.
17. Wollenweber, S. D., D. S. Lalush, B. M. W. Tsui, and G. T. Gullberg, "Evaluation of myocardial defect detection between parallel-hole and fan-beam SPECT using the Hotelling trace," IEEE Transactions on Nuclear Science, vol. 45, pp. 2205-2210, 1998.
18. Segars, W. P., D. S. Lalush, and B. M. W. Tsui, “A realistic spline-based dynamic heart phantom,” IEEE Transactions on Nuclear Science, vol. 46, pp. 503-506, 1999.
19. Wollenweber, S. D., B. M. W. Tsui, D. S. Lalush, E. C. Frey, K. J. LaCroix, and G. T. Gullberg, “Comparison of Hotelling observer models and human observers in defect detection from myocardial SPECT imaging,” IEEE Transactions on Nuclear Science, vol. 46, pp. 2098-2103, 1999.

1. Segars, W. P., D. S. Lalush, and B. M. W. Tsui, “Modeling respiratory mechanics in the MCAT and spline-based MCAT phantoms,” submitted to IEEE Transactions on Nuclear Science, 2000.

1. Lalush, D. S., and B. M. W. Tsui, "Optimization of Gibbs priors based on object size and contrast for maximum a posteriori SPECT reconstruction," Conference Record of the 1992 IEEE Nuclear Science Symposium, Orlando, Florida, pp. 1023-1025, 1992.
2. Lalush, D. S., and B. M. W. Tsui, "MAP-EM and WLS-MAP-CG reconstruction methods for transmission imaging in cardiac SPECT," Conference Record of the 1993 IEEE Nuclear Science Symposium, San Francisco, California, pp. 1174-1178, 1993.
3. Lalush, D. S., and B. M. W. Tsui, "The importance of preconditioners in fast Poisson-based iterative reconstruction algorithms for SPECT," Conference Record of the 1995 IEEE Nuclear Science Symposium, San Francisco, California, pp. 1326-1330, 1995.
4. Lalush, D. S., L. Cui, and B. M. W. Tsui, "A priori motion models for four-dimensional reconstruction in gated cardiac SPECT," Conference Record of the 1996 IEEE Nuclear Science Symposium, Anaheim, California, 1996.
5. Lalush, D. S., S. Karimi, and B. M. W. Tsui, "Convergence and resolution recovery of block-iterative EM algorithms modeling 3D detector response in SPECT," Conference Record of the 1996 IEEE Nuclear Science Symposium, Anaheim, California, 1996.
6. Lalush, D. S. and D. E. Wessell, "A linear shift-variant model for local point response in circular-orbit cone-beam iterative reconstruction," 1997 IEEE Nuclear Science Symposium Conference Record, Albuquerque, New Mexico, 1997.
7. Lalush, D. S., W. P. Segars, and B. M. W. Tsui, “A unified approach to 4D gated myocardial SPECT reconstruction,” 1999 Nuclear Science Symposium Conference Record, Seattle, Washington, 1999.

BMME 120 Real-Time Computer Applications

BMME 231 Fundamentals of Image Processing

BMME 253 Advanced Medical Image Processing (partial)