Title:

Associate Professor

Office Information:

111 Mason Farm Rd
MBRB Room 4337
Campus Box 7032
UNC Chapel Hill
(919) 966-6816

Education:

PhD, Genetics and Molecular Biology, University of North Carolina at Chapel Hill
BS, Chemistry/Biochemistry, University of California at San Diego

Email:

magness@med.unc.edu

Lab Site:

http://www.magnesslab.org

Research and Publications:

Research Area: Regenerative Medicine

Secondary Research Area:  Biomedical Microdevices

Research Interests:  Stem Cell Biology, Niche Dynamics, Tissue Engineering, Biomimetic Scaffolds, Single-Cell Biology, Stem cell maintenance and differentiation, Single cell analytics, High-throughput biomimetic culture platforms

Research:

Dr. Magness' research is focused on the basic biology of intestinal stem cells, the genes that control their behavior, and translational approaches to stem cell based therapies for human disease and injury of the intestine. Furthermore his research focuses on elucidating genetic mechanisms underlying stemness and developing translational models to establish a finer understanding of stem cell-driven regeneration dynamics in homeostasis and injury. Using a combination of genetic mouse models and micro-frabricated bioengineered platforms, Dr. Magness’ team is exploiting the self-renewal capacity and multipotency of ISCs to develop long-term ex vivo models of the intestine and colon with primary tissues. These biomimetic models offer new solutions for compound screening and cell-based therapies.

 

Selected Publications:

Roche KC, Gracz AD, Liu XF, Newton V, Akiyama H, Magness ST – Sox9 maintains reserve stem cells and preserves radio-resistance in mouse small intestine. Gastroenterology, 2015, Jul 10. pii: S0016-5085(15)00941-5.

Link