111 Mason Farm Rd MBRB Room 4337 Campus Box 7032 UNC Chapel Hill (919) 966-6816
PhD, Genetics and Molecular Biology, University of North Carolina at Chapel Hill BS, Chemistry/Biochemistry, University of California at San Diego
Research and Publications:
Research Area: Regenerative Medicine
Secondary Research Area: Biomedical Microdevices
Research Interests: Stem Cell Biology, Niche Dynamics, Tissue Engineering, Biomimetic Scaffolds, Single-Cell Biology, Stem cell maintenance and differentiation, Single cell analytics, High-throughput biomimetic culture platforms
Dr. Magness' research is focused on the basic biology of intestinal stem cells, the genes that control their behavior, and translational approaches to stem cell based therapies for human disease and injury of the intestine. Furthermore his research focuses on elucidating genetic mechanisms underlying stemness and developing translational models to establish a finer understanding of stem cell-driven regeneration dynamics in homeostasis and injury. Using a combination of genetic mouse models and micro-frabricated bioengineered platforms, Dr. Magness’ team is exploiting the self-renewal capacity and multipotency of ISCs to develop long-term ex vivo models of the intestine and colon with primary tissues. These biomimetic models offer new solutions for compound screening and cell-based therapies.
Roche KC, Gracz AD, Liu XF, Newton V, Akiyama H, Magness ST – Sox9 maintains reserve stem cells and preserves radio-resistance in mouse small intestine. Gastroenterology, 2015, Jul 10. pii: S0016-5085(15)00941-5.