Assistant Professor of Biomedical Engineering; Primary faculty - UNC Neuroscience Center and Carolina Institute for Developmental Disabilities
4340C MBRB UNC Chapel Hill (919) 843-8156
Postdoc, California Institute of Technology Ph.D. Biomedical Engineering, University of California, Irvine B.S. Civil Engineering, B.S. Engineering and Public Policy, Washington University in St. Louis
Research and Publications:
Research Area: Biomedical Microdevices
Research Interests: Micro-Scale Devices, Microfluidics, Synapse Formation, Synaptic Plasticity, Protein Synthesis
Research: Our lab exploits micro-scale technology and microfluidics as experimental tools to spatially and temporally probe synapses of the CNS. We are also focused on basic science research, using these tools to understand the role of local translation during synapse development and how synapse function is altered following injury and in neurodevelopmental disorders. We are interested in developing therapeutic strategies that have clinical relevance to promote proper synapse re-formation and circuit development.
1. Taylor, A.M., Menon, S. and Gupton, S.L., Passive microfluidic chamber for long-term imaging of axon guidance in response to soluble gradients. Lab on a Chip (2015) DOI: 10.1039/C5LC00503E
2. Niedringhaus, M., Dumitru, R., Mabb, A., Wang, Y., Philpot, B.D., Allbritton, N.L., and Taylor, A.M. Transferable neuronal mini-cultures to accelerate screening in primary and induced pluripotent stem cell-derived neurons. Sci Rep (Nature), (2015) 5:8353 DOI: 10.1038/srep08353 ** highlighted in the Simons Foundation SFARI newsletter Apr. 14, 2015 "Tiny square rafts help neurons thrive in lab"
3. Tayor, A.M.*, Wu, J.R., Tai, H.-C. & Schuman, E.M.* Axonal translation of beta-catenin regulates synaptic vesicle dynamics. Journal of Neuroscience (2013) *corresponding authors
4. Hallfors, N., Khan, A., Dickey, M.D., & Taylor, A.M. Integration of pre-aligned liquid metal electrodes for neural stimulation within a user-friendly microfluidic platform. Lab on a Chip (2013) 13(4): 522-6
5. Taylor, A.M., Dieterich, D.C., Ito, H. T., Kim, S.A. & Schuman, E.M. Microfluidic local perfusion chambers for the visualization and manipulation of synapses. Neuron (2010) 66, 57-68
6. Taylor, A.M., Berchtold, N.C., Perreau, V.M., Tu, C.H., Jeon, N.L. & Cotman, C.W. Axonal mRNA in uninjured and regenerating cortical mammalian axons. Journal of Neuroscience (2009) 29: 4697-4707 ** highlighted in 'This Week in the Journal' [Journal of Neuroscience 2009; 29(15)] ** highlighted in 'The Neuroscientist Comments' [Neuroscientist 2009; 15; 414]