| Projects |
| (Sort by Personnel) |
| Project Areas:
Tensile Strain Bioreactor Primary Cilia Chondrogenesis Fluid Shear Meniscal Allografts Finite Element Modeling Scaffold Development |
Fluid Shear Stress in hASC |
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| Overall Project Goal |
The overall goal of the fluid shear stress analysis project is to ultimately create a bioabsorbable scaffold seeded with hASCs that could be implanted in donor bone wound sites. The goal is that these scaffolds would be able to speed fracture recovery as the scaffold puts a bolus of bone-like cells right at the injury site. | ||
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Researchers & Specific Projects |
Daniel Cunningham
Daniel's project focuses on researching the osteogenic effect of fluid shear stress on human adipose-derived stem cells (hASCs). He seeds the hASCs on porous, biodegradable scaffolds and force media through the scaffolds to induce shear stresses on the cells just as fluid moving through bone canaliculi in vivo puts shear stress on osteocytes. The resulting shear stress causes gene expression changes in the hASCs resulting in the hASCs exhibiting bone cell-like behavior. This project also relates to the overall scaffolds project. |
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