|Professor of Biomedical Engineering
John A. McNeill Distinguished Professor and Vice Dean, UNC School of Pharmacy
|Postdoc, 1991-1992, Protein Drug Delivery, University of Washington Center for Bioengineering
Ph.D, 1991, Pharmaceutical Sciences, University of Kentucky College of Pharmacy
BA, 1988, Chemistry, University of Ketucky
|1044 Genetic Medicine Building
UNC Chapel Hill
Chapel Hill, NC
|Dr. Mumper’s research program is focused primarily in five areas:
1. Nanotemplate engineering of nano-based detection devices and cell-specific nanoparticles for tumor and dendritic cell targeting and vaccines. Current projects relate to using nanotechnology to target and overcome multi-drug resistant cancer, and as vaccine delivery systems for HIV proteins and adjuvants
2. Biocompatibility, hemocompatibility, and toxicology of nanoparticles and nanomaterials
3. Drug-polymer conjugates
4. Mucoadhesive gels and thin-films for (trans)mucosal delivery of drugs, vaccines, and microbicides
5. Anticancer and anti-inflammatory properties of berries and berry extracts
|1. S Wadhwa, and RJ Mumper. Poly-l-glutamic Acid Conjugation Enhances the Intra-Cellular Delivery and Cytoxicity of the Reactive Oxygen Species Generating Agent D-penicillamine. Submitted to Bioconjugate Chemistry.
2. Q Zhu, J Talton, G Zhang, T Cunningham, J Kirk, B Epper, DM Klinman, I M Belyakov, Y Sui, S Gagnon, RJ Mumper, and JA Berzofsky. Oral Targeting of Nanoparticle Vaccine to the Large Intestine to Combat Genitorectal Viral Transmission. Submitted to Science.
3. W Yan, A Jain, R O’Carra, JG Woodward, W Li, G Li, A Nath and RJ Mumper. Lipid Nanoparticles with Accessible Nickel as a Vaccine Delivery System for Single and Multiple His-tagged HIV Antigens. HIV/AIDS - Research and Palliative Care. (2009) 1:1-11.
4. X Dong, CA Mattingly, M Tseng, M Cho, Y Liu, VR Adams, and RJ Mumper. Doxorubicin and Paclitaxel- loaded Lipid-based Nanoparticles Overcome Multi-Drug Resistance By Inhibiting P-gp via ATP Depletion. Cancer Research. (2009) 69:3918-3926.
5. P Ma, X Dong, CL Swadley, A Gupte, M Leggas, HC Ledebur, and RJ Mumper. Development of Idarubicin and Doxorubicin Solid Lipid Nanoparticles to Overcome Pgp–mediated Multiple Drug Resistance in Leukemia. J. Biomed. Nanotech. (2009) 5:151-161.