|Ph.D. Chemistry, The Pennsylvania State University
M.S. Mechanical Engineering, The Pennsylvania State University
B.S. Engineering Science, The Pennsylvania State University
|4208D Engineering Building III|
|NC State University|
|Bioelectric Stimulation, BioMEMS, Nanometer Systems, Intelligent Systems, Biomedical Sensors|
|The goal of the McCarty Research Group is to improve the biomedical infrastructure for in vivo molecular monitoring and to apply this infrastructure to research on neurological disease treatments. The ability to monitor the biochemical environment and fluctuations in neurochemical levels in vivo is critical to understanding how pharmacological treatments are affecting brain function. Specifically, we plan to advance our existing molecular monitoring technologies, microfabricated interface platforms, by increasing their functionality and to apply the infrastructure to study common neurological treatments, gaining insights into their mechanisms of action. The McCarty Group has developed the technology to make these measurements in vivo. The McCarty Research Group has a broad background in chemistry, physics and engineering which it applies to cutting edge research in biomedical measurements and specifically in molecular monitoring in vivo. Recently the Group’s research emphasis was on creating novel nanostructures and nanotechnologies for molecular monitoring. Currently the McCarty Research Group is collaborating with Dr. R. Mark Wightman and Dr. Leslie Sombers. Both are experts in molecular monitoring in vivo for neuroscience.|
|1) M. K. Zachek, J. Park, P. Takmakov, R. M. Wightman, G. S. McCarty “Microfabricated FSCV-Compatible Microelectrode Array for Real-time Monitoring of Heterogeneous Dopamine Release” in press Analyst (2010).
2) B. P. Moody, J. Leotaud, G. S. McCarty “Using Surface Enhanced Raman Spectroscopy to Probe for Genetic Markers on ssDNA.” Journal of Biomedical Optics in press (2010).
3) G. S. McCarty, B. P. Moody & M. K. Zachek “Enhancing Electrochemical Detection by Scaling Solid State Nanogaps.” Journal of Electroanalytical Chemistry in press (2010).
4) J. G. Roberts, B. P. Moody, G. S. McCarty & L. A. Sombers “Specific Oxygen-Containing Functional Groups on the Carbon Surface Underlie an Enhanced Sensitivity to Dopamine at Electrochemically Pretreated Carbon Fiber Microelectrodes” Langmuir (2010) ASAP DOI: 10.1021/la9048924.
5) P. Takmakov, M. K. Zachek, R. B. Keithley, P. L. Walsh, C. Donley, G. S. McCarty & R. M. Wightman “Carbon Microelectrodes with a Renewable Surface” Analytical Chemistry 82, (2010) 2020–2028.
6) M. K. Zachek, P. Takmakov, J. Park, R. M. Wightman & G. S. McCarty “Simultaneous monitoring of dopamine concentration at spatially different brain locations in vivo.” Biosensors and Bioelectronics 25, (2010) 1179-1185.
7) M. K. Zachek, P. Takmakov, B. P. Moody, R. M. Wightman & G. S. McCarty “Simultaneous Decoupled Detection of Dopamine and Oxygen Using Pyrolyzed Carbon Microarrays and Fast-Scan Cyclic Voltammetry.” Analytical Chemistry 81, (2009) 6258-6265.
8) B. P. Moody, B. & G. S. McCarty “Solid state nanogaps for differential measurements of molecular properties.” Applied Physics Letters 94, (2009) Article No. 122104.
9) B. P. Moody & G. S. McCarty “Statistically Significant Raman Detection of Midsequence Single Nucleotide Polymorphisms.” Analytical Chemistry 81, (2009) 2013-2016.
10) M. K. Zachek, A. Hermans, R. M. Wightman & McCarty, G. S. “Electrochemical Dopamine Detection: Comparing Gold and Carbon Fiber Microelectrodes using Background Subtracted Fast Scan Cyclic Voltammetry.” Journal of Electroanalytical Chemistry 614, (2008) 113-120.
11) T. A. Daniel, S. Uppili, G. S. McCarty & D. L. Allara “Effects of molecular structure and interfacial ligation on the precision of Cu-bound alpha,omega-mercaptoalkanoic acid "molecular ruler" stacks.” Langmuir 23, (2007) 638-648.