Novel In Situ Imaging and Measurement Technologies for Biological Systems Science / Sponsor:  United States Department of Energy (DOE) / Website:  http://www.grants.gov/view-opportunity.html?oppId=264552 / Sponsor ID: DE-FOA-0001192 / Amount:  It is anticipated that up to $5,000,000 from BER, Biological Systems Science will be available for approximately 4 to 6 awards to be made in Fiscal Year 2015, contingent on the availability of appropriated funds. / Abstract:  The Office of Biological and Environmental Research (BER) of the Office of Science (SC), U.S. Department of Energy (DOE) hereby announces its interest in receiving research applications for novel imaging and measurement technologies for biological systems science. This Funding Opportunity Announcement (FOA) will consider applications for the development of novel imaging instrumentation and measurement technologies that support the integrative analysis of communication among subcellular compartments, between individual microbial cells and within multicellular communities/plant tissues. The goal is to develop in situ, dynamic and nondestructive approaches to enable multifunctional imaging, quantitative flux measurements, and multiscale integrative analysis of bioenergy-relevant plant and microbial systems. Ideally, these imaging approaches will pave the way for predictive understanding of the spatial and temporal relationships, physical connections, and chemical exchanges that facilitate the flow of materials and information across membranes and between intracellular spaces. The anticipated outcome of this FOA is the development of in situ imaging and measurement technologies that can (1) resolve multiple key metabolic processes over time within or among cells and (2) bridge the critical gap in linking molecular-scale information to whole-cell, systems-level understanding. / Deadline:  10/15/2014

Information and Intelligent Systems (IIS): Core Programs / Website:  http://www.nsf.gov/funding/pgm_summ.jsp?pims_id=13707 / Sponsor:  National Science Foundation (NSF) / Sponsor ID: NSF 14-596 / Abstract:  IIS studies the inter-related roles of people, computers, and information. IIS supports research and education activities that (1) develop new knowledge about the role of people in the design and use of information technology; (2) increase our capability to create, manage, and understand data and information in circumstances ranging from personal computers to globally-distributed systems; and (3) advance our understanding of how computational systems can exhibit the hallmarks of intelligence. / Deadlines:  11/10/2014; 01/15/2015

(Re)Building a Kidney Coordinating Center (U01) / Website:  http://grants.nih.gov/grants/guide/rfa-files/RFA-DK-14-009.html / Sponsor:  National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) / Sponsor ID: RFA-DK-14-010, RFA-DK-14-009 / Amount:  NIDDK intends to commit a total of $3 million in FY 2015. One award for up to $1.6M will be made under this FOA to a Coordinating Center. / Abstract:  This Funding Opportunity Announcement (FOA) is a new initiative to invite applications to participate in the Kidney Consortium as the Coordinating Center. The consortium Coordinating Center will manage activities of the consortium including research opportunities (e.g., the Opportunity Pool program), and facilitate communication of research results, data, and methods within the consortium and with the community. / Deadline:  01/14/2015

Grand Challenges in Global Health Initiative: Grand Challenges Explorations Grand Challenges Explorations Round 14 / Website:  http://www.grandchallenges.org/Explorations/Pages/ApplicationInstructions.aspx / Sponsor:  Gates Foundation, Bill and Melinda  / Amount:  Awards of $100,000 USD are made in Phase I. Phase I awardees have one opportunity to apply for a follow-on Phase II award of up to $1,000,000 USD. / Abstract:  The initiative fosters scientific and technological innovation to solve key health problems in the developing world. The initiative supports early-stage research projects – including many ideas that have never before been tested – and individuals from a wide range of disciplines and regions. The GCE initiative funds innovative ideas that could lead to new vaccines, diagnostics, drugs, and other technologies targeting diseases that claim millions of lives every year, as well as improvements and innovations in agriculture development and others of the Foundation priority areas. Proposals will be accepted for projects focusing on six topics: 1. Surveillance Tools, Diagnostics and an Artificial Diet to Support New Approaches to Vector Control: In the case of Aedes and Anopheles mosquitoes (those that carry malaria, lymphatic filariasis, dengue, chikungunya, yellow fever, and Zika fever), new approaches that are proven in the lab need to scale up production and they need to be monitored in proof of concept studies. New technologies are required to support these next steps; 2. New Approaches for Addressing Outdoor/Residual Malaria Transmission: In many settings, residual transmission is or will be of sufficient magnitude to render eradication of malaria infeasible with complementary diagnosis and treatment interventions alone; 3. New Ways to Reduce Pneumonia Fatalities Through Timely, Effective Treatment of Children: The Foundation is focusing its explorations topic on finding novel ideas that will help diminish mortality among children with pneumonia leveraging known potential for amoxicillin treatment, pulse oximetry and oxygen supplementation through oxygen concentrators. It is looking for innovative ideas in the following specific areas of interest under this exploration: a. Child friendly formulations of amoxicillin; b. Optimizing Oxygen concentrators; c. Devices for measuring oxygen saturation (or optimizing pulse oximetry); 4. Enable Universal Acceptance of Mobile Money Payments; 5. Explore New Ways to Measure Brain Development and Gestational Age: This call for proposals seeks new approaches in two complementary areas: a. The Foundation seeks innovative ideas for measuring brain function and development, with a focus on tests that are simple, reliable, non-invasive, objective, universally applicable, and include those appropriate for fetal life, newborns, and early infancy. Such tests would be used to guide and monitor existing and new health interventions, and potentially could be used to establish standard curves of brain function-for-age, enabling early detection of deviation from healthy development; b. The Foundation seeks new approaches for accurately measuring gestational age, focusing on simple, reliable, non-invasive, universally applicable tests that can be applied either to pregnant women or to the newborn or infant; 6. New Ways of Working Together: Integrating Community-Based Interventions: The aim of this call is to solicit innovative ideas to leverage existing MDA platforms for one or more of the five NTD drug distribution efforts (lymphatic filiariasis, onchocerciasis, trachoma, schistosomiasis, and soil transmitted helminthes) and integrate it with another community-valued or needed health intervention or agricultural service with a goal of increasing efficiency and impact. / Deadline:  11/12/2014